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12 Jan
2018

Professors from HKU are Researching New Drugs to Tackle MRSA

(Chinese version only)

<Hong Kong Economic Times>

袁國勇任顧問 料3年內臨床試驗

港大教授成立生物醫藥公司Acticule,專注研發對抗惡菌的針對性藥物。

該公司重點項目的新藥可擊破超級惡菌「抗藥性金黃葡萄球菌」(MRSA)的「黃金盔甲」,令人體免疫系統自行打敗惡菌,料3年內可開展臨床試驗。
港大微生物學系副教授高一村於今年創立生命科學公司Acticule,該公司有不少猛人加盟,多名港大教授出任該公司的科研顧問,包括港大微生物學系傳染性疾病講座教授袁國勇,現已獲母公司生命科學集團投資300萬美元(約2,346萬港元)。

高稱,目標研發針對性藥物,醫治現有各類嚴重傳染病,希望未來能令每種惡菌均有至少一至兩種的專門藥物。

令免疫系統 自行打敗細菌

他研究多年的MRSA將是其中重點項目之一,他指出,傳統做法用抗生素殺死細菌,減低細菌數目,惟現時抗藥性金黃葡萄球菌對多種抗生素已產生抗藥性,可用的抗生素品種不多,而且抗生素是無法將細菌完全殺死,小部分細菌突變後可存活,然後快速繁殖,此後再用抗生素便會失效。
高形容,超級惡菌的金黃色葡萄球菌素猶如盔甲,擋住人體免疫系統產生的活性氧分子,使其無法殺死細菌。新藥利用一種NP16化合物,不會直接殺死細菌,但可終止製造「黃金盔甲」,令細菌由金黃色變成白色,無法再繁殖和感染,而免疫系統可自行打敗細菌。他保守估計,3年內可開展臨床測試,又指藥物若成功推出,不論是醫院型或社區型的金黃葡萄球菌,均可有效對抗。

另一重點項目是研發針對流感病毒核蛋白的藥物,若缺少核蛋白,流感病毒將無法複製和增生;假如用此藥物混合其他流感藥物特敏福和樂感清,類似「雞尾酒療法」,可發揮更大功效。目前研究方向針對甲型流感,正準備進行臨床前研究,料1年後可作首期臨床研究。

獲投資2300萬 有望再加碼

Acticule母公司為生命科學集團知臨集團,該集團行政總裁兼執行董事禤駿遠透露,已投放300萬美元於Acticule作臨床前研究之用,未來會視乎美國食品藥物管理局(FDA)對臨床實驗的要求再加碼。

禤又稱,集團亦有投資於研究及早發現腦退化症的方法。他指,要早期發現腦退化並不容易,現時需要抽取骨髓作化驗或進行「澱粉狀蛋白--正電子腦掃描」(PET-scan),但他們正現研究打顯影劑於體內,再透過磁力共振找出病徵,更為方便和便宜,已作動物實驗證明有效,料1年多後可進行首期臨床實驗。

金主父親曾染沙士 決投資醫學

Acticule背後金主為知臨集團,集團行政總裁及執行董事禤駿遠本身是ibanker,但因03年沙士時,父親不幸感染而須隔離,才開始投資醫學。
禤駿遠憶述,03年父親不幸感染沙士要到威爾斯醫院留院,他們一家人要被隔離,「當時每日看電視最希望袁國勇出來,說他已找到治療沙士的方法。」這次經歷對他影響深遠,他放棄了當投行「賓架」,全力投資醫學。

昔冀袁國勇 找到治沙士方法

5年前,禤駿遠成立知臨集團,主力投資北美醫學研究,直到3年前發現香港醫學研究甚具質素,只是欠缺資金,以及可將科研變商品的人才,故轉戰到港投資。
該集團商務總監及總裁雷宏業指,集團共投資5,000萬美元(約3.9億港元)於科研上,現投資20多個項目,大多是本地大學的科研,範疇包括腦退化、機械人手術(Robotic Surgery)等。而集團在港成立兩個實驗室,一個面積約1,000呎位於科學園,另一個約3,000呎位於中文大學。他透露,集團旗下職員現時約40多人,而當中10人是實驗室研究員,一直增聘人手,未來會再開設新實驗室,將科研成果商品化,希望留住本地人才於香港。

11 Nov
2017

Learn Management Skills from Ancient Chinese Businessman

(Chinese version only)

主持人:陳志輝、冼日明、 潘嘉陽、李靜宜、程潔明
嘉賓:禤駿遠(知臨集團首席執行官及創始人)

11 Nov 2017@ 香港電台第一台

20 Sep
2017

高浩博士@嘉事專題

高浩博士@嘉事專題

高浩博士在嘉事專訪接受訪問@ 11:49

20 Sep 2017@ 嘉事專題

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